MITOCHONDRIAL & LONGEVITY
SS-31
Mitochondria-targeted tetrapeptide (elamipretide). Investigated in cardiolipin-binding research.
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Certificate of Analysis
Third-party tested · ISO/IEC 17025 accredited
99.2%
purity
✓ Passed full QC panel
- Variant
- SS-31 · 10 mg
- Lot #
- AML-2026-0525
- Labeled
- 10 mg
- Tested
- 2026-04-25
Full QC panel
- Purity (HPLC)
- 99.2%
- Net Peptide Content
- Pass
- Identity (HPLC-MS)
- Confirmed
- Heavy Metals (ICP-MS)
- Not detected
- Sterility
- No growth
- Endotoxin (LAL)
- Within limits
Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.
Compound Information
Chemical and structural properties
Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.
Molecular profile
Structure
- CAS Number
- 736992-21-5
- Molecular Formula
- C32H49N9O5
- Molecular Weight
- 639.8 g/mol
- Sequence
- D-Arg-Dmt-Lys-Phe-NH2
- Type
- Research peptide
- PubChem
- CID 11764719 ↗
Biological targets
Interactions
- Primary target
- Cardiolipin (inner mitochondrial membrane)
- Pathway
- Cardiolipin stabilization; electron-transport efficiency; ROS reduction
- Mechanism
- Mitochondria-targeting tetrapeptide that binds cardiolipin
- Research area
- Mitochondrial dysfunction, cardiac and renal research
Physical properties
Handling & Storage
- Appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in water; reconstitute prior to use
- Storage
- 2-8 deg C, protect from light
- Country of origin
- USA
Sources & References
Peer-reviewed research
Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
2025 · PMID 39940712
Tung C et al.
View Source ↗INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury
2025 · PMID 40244206
Ravenscraft B et al.
View Source ↗JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin
2013 · PMID 23813215
Birk AV et al.
View Source ↗PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Mitochondrial protein interaction landscape of SS-31
2020 · PMID 32554501
Chavez JD et al.
View Source ↗THE JOURNAL OF BIOLOGICAL CHEMISTRY
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action
2020 · PMID 32273339
Mitchell W et al.
View Source ↗
⚠ Important research notice
PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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