BIOREGULATORS
Pancragen
Khavinson-class peptide bioregulator. Investigated in pancreatic tissue research literature.
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Certificate of Analysis
Third-party tested · ISO/IEC 17025 accredited
—
purity
✓ Passed full QC panel
- Variant
- Pancragen · 20 mg
- Lot #
- —
- Labeled
- 20 mg
- Tested
- —
Full QC panel
- Purity (HPLC)
- —
- Net Peptide Content
- Pass
- Identity (HPLC-MS)
- Confirmed
- Heavy Metals (ICP-MS)
- Not detected
- Sterility
- No growth
- Endotoxin (LAL)
- Within limits
Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.
Compound Information
Chemical and structural properties
Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.
Molecular profile
Structure
- CAS Number
- —
- Molecular Formula
- C26H36N6O9
- Molecular Weight
- 576.6 g/mol
- Sequence
- —
- Type
- Research peptide
- PubChem
- CID 68452877 ↗
Biological targets
Interactions
- Primary target
- No canonical receptor; proposed sequence-specific DNA / promoter binding in pancreatic cells
- Pathway
- PDX1 / NGN3 / PAX6 transcription-factor expression; acinar and islet differentiation (proposed)
- Mechanism
- Synthetic tetrapeptide (Lys-Glu-Asp-Trp) studied as a pancreas-directed bioregulator
- Research area
- Pancreatic cell differentiation, glucose-metabolism and aging research
Physical properties
Handling & Storage
- Appearance
- White lyophilized powder
- Solubility
- Soluble in water; reconstitute prior to use
- Storage
- 2-8 deg C, protect from light
- Country of origin
- USA
Sources & References
Peer-reviewed research
Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.
ADVANCES IN GERONTOLOGY = USPEKHI GERONTOLOGII
[Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys]
2014 · PMID 25946840
Goncharova ND et al.
View Source ↗ADVANCES IN GERONTOLOGY = USPEKHI GERONTOLOGII
[Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys]
2015 · PMID 28509500
Goncharova ND et al.
View Source ↗BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Effects of pancragen on the differentiation of pancreatic cells during their ageing
2013 · PMID 23486591
Khavinson VKh et al.
View Source ↗ADVANCES IN GERONTOLOGY = USPEKHI GERONTOLOGII
[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]
2006 · PMID 17152728
Zakutskiĭ AN et al.
View Source ↗BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide
2010 · PMID 21246099
Khavinson VKh et al.
View Source ↗
⚠ Important research notice
PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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