GROWTH HORMONE FAMILY

IGF-1 LR3

Long-acting IGF-1 analog (Arg3 substitution + 13-aa N-terminal extension). Researched in IGF-pathway literature.

1 mgRUO · RESEARCH USE ONLY$59.00

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Certificate of Analysis

Third-party tested · ISO/IEC 17025 accredited

LATESTISO 170257+ TESTING

99%

purity

✓ Passed full QC panel

Variant
IGF-1 LR3 · 1 mg
Lot #
AML-2026-0520
Labeled
1 mg
Tested
2026-04-20

Full QC panel

Purity (HPLC)
99%
Net Peptide Content
Pass
Identity (HPLC-MS)
Confirmed
Heavy Metals (ICP-MS)
Not detected
Sterility
No growth
Endotoxin (LAL)
Within limits
VIEW COA →

Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.

Compound Information

Chemical and structural properties

Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.

Molecular profile

Structure

CAS Number
946870-92-4
Molecular Formula
—
Molecular Weight
9117.5 g/mol
Sequence
(83 aa; see protein databank)
Type
Research peptide

Biological targets

Interactions

Primary target
IGF-1 receptor (IGF1R)
Pathway
IGF1R–PI3K / Akt and MAPK; reduced IGFBP binding (LR3)
Mechanism
Long-R3 IGF-1 analog with extended half-life and low IGFBP affinity
Research area
Growth, cell-proliferation and metabolic research

Physical properties

Handling & Storage

Appearance
White lyophilized powder
Solubility
Soluble in dilute acetic acid or sterile water
Storage
2-8 deg C, protect from light
Country of origin
USA

Sources & References

Peer-reviewed research

Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.

  • AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM

    IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep

    2025 · PMID 39679943

    White A et al.

    View Source ↗

  • JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE

    Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets

    2023 · PMID 37114757

    White A et al.

    View Source ↗

  • APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

    Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris

    2023 · PMID 37261455

    Lu Z et al.

    View Source ↗

  • FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY

    Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep

    2020 · PMID 32573852

    Jonker SS et al.

    View Source ↗

  • INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

    N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling

    2022 · PMID 36499281

    Salvi R et al.

    View Source ↗

⚠ Important research notice

PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.

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US Manufactured

Manufactured in our U.S. ISO Class 5 sterile facility under cGMP-aligned controls. Every step—from raw material qualification through final lot release—is completed domestically. Every production lot is batch-specific and fully traceable, ensuring consistent quality and manufacturing integrity.

Independent Testing

Every batch undergoes independent verification, including HPLC purity, mass spectrometry, endotoxin screening, sterility testing, heavy metals analysis, peptide identity confirmation, and quantitative peptide content. A complete Certificate of Analysis (COA) is published for every lot.

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Orders placed before 12:00 PM EST are typically shipped the same business day from our U.S. fulfillment facility, conveniently located near our manufacturing operations. Products are securely stored in a temperature-controlled environment and professionally managed to help preserve product quality, ensure rapid order fulfillment, and support time-sensitive research.

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