GROWTH HORMONE FAMILY
IGF-1 LR3
Long-acting IGF-1 analog (Arg3 substitution + 13-aa N-terminal extension). Researched in IGF-pathway literature.
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Certificate of Analysis
Third-party tested · ISO/IEC 17025 accredited
99%
purity
✓ Passed full QC panel
- Variant
- IGF-1 LR3 · 1 mg
- Lot #
- AML-2026-0520
- Labeled
- 1 mg
- Tested
- 2026-04-20
Full QC panel
- Purity (HPLC)
- 99%
- Net Peptide Content
- Pass
- Identity (HPLC-MS)
- Confirmed
- Heavy Metals (ICP-MS)
- Not detected
- Sterility
- No growth
- Endotoxin (LAL)
- Within limits
Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.
Compound Information
Chemical and structural properties
Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.
Molecular profile
Structure
- CAS Number
- 946870-92-4
- Molecular Formula
- —
- Molecular Weight
- 9117.5 g/mol
- Sequence
- (83 aa; see protein databank)
- Type
- Research peptide
Biological targets
Interactions
- Primary target
- IGF-1 receptor (IGF1R)
- Pathway
- IGF1R–PI3K / Akt and MAPK; reduced IGFBP binding (LR3)
- Mechanism
- Long-R3 IGF-1 analog with extended half-life and low IGFBP affinity
- Research area
- Growth, cell-proliferation and metabolic research
Physical properties
Handling & Storage
- Appearance
- White lyophilized powder
- Solubility
- Soluble in dilute acetic acid or sterile water
- Storage
- 2-8 deg C, protect from light
- Country of origin
- USA
Sources & References
Peer-reviewed research
Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep
2025 · PMID 39679943
White A et al.
View Source ↗JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
2023 · PMID 37114757
White A et al.
View Source ↗APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris
2023 · PMID 37261455
Lu Z et al.
View Source ↗FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY
Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep
2020 · PMID 32573852
Jonker SS et al.
View Source ↗INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling
2022 · PMID 36499281
Salvi R et al.
View Source ↗
⚠ Important research notice
PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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