MITOCHONDRIAL & LONGEVITY
FOXO4-DRI
Retro-inverso FOXO4 peptide. Investigated in cellular senescence research literature.
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Certificate of Analysis
Third-party tested · ISO/IEC 17025 accredited
—
purity
✓ Passed full QC panel
- Variant
- FOXO4-DRI · 10 mg
- Lot #
- —
- Labeled
- 10 mg
- Tested
- —
Full QC panel
- Purity (HPLC)
- —
- Net Peptide Content
- Pass
- Identity (HPLC-MS)
- Confirmed
- Heavy Metals (ICP-MS)
- Not detected
- Sterility
- No growth
- Endotoxin (LAL)
- Within limits
Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.
Compound Information
Chemical and structural properties
Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.
Molecular profile
Structure
- CAS Number
- 2460055-10-9
- Molecular Formula
- C228H388N86O64
- Molecular Weight
- 5358 g/mol
- Sequence
- —
- Type
- Research peptide
- PubChem
- CID 167312269 ↗
Biological targets
Interactions
- Primary target
- FOXO4–p53 protein–protein interface; p53 transactivation domain (proposed)
- Pathway
- FOXO4–p53 dissociation; p53 nuclear exclusion; intrinsic apoptosis in senescent cells
- Mechanism
- Retro-inverso D-amino-acid FOXO4 peptide; competes with FOXO4 for p53 binding
- Research area
- Cellular senescence, senolytic and aging research
Physical properties
Handling & Storage
- Appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in sterile or bacteriostatic water; reconstitute prior to use
- Storage
- 2-8 deg C, protect from light
- Country of origin
- USA
Sources & References
Peer-reviewed research
Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.
CIRCULATION
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
2023 · PMID 36515093
Born E et al.
View Source ↗NATURE COMMUNICATIONS
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
2025 · PMID 40593617
Bourgeois B et al.
View Source ↗COMMUNICATIONS BIOLOGY
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation
2025 · PMID 39994346
Kong YX et al.
View Source ↗AGING
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
2020 · PMID 31959736
Zhang C et al.
View Source ↗FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
2025 · PMID 41625068
Hu Z et al.
View Source ↗
⚠ Important research notice
PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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