HEALING & RECOVERY
ARA-290
Erythropoietin-derived 11-amino-acid peptide (cibinetide). Investigated in innate repair receptor research.
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Certificate of Analysis
Third-party tested · ISO/IEC 17025 accredited
—
purity
✓ Passed full QC panel
- Variant
- ARA-290 · 16 mg
- Lot #
- —
- Labeled
- 16 mg
- Tested
- —
Full QC panel
- Purity (HPLC)
- —
- Net Peptide Content
- Pass
- Identity (HPLC-MS)
- Confirmed
- Heavy Metals (ICP-MS)
- Not detected
- Sterility
- No growth
- Endotoxin (LAL)
- Within limits
Purity, lot and tested date are per-lot; remaining QC rows are representative — exact values on the CoA.
Compound Information
Chemical and structural properties
Chemical identity verified via NIH PubChem · biological targets characterized from the peer-reviewed literature.
Molecular profile
Structure
- CAS Number
- 1208243-50-8
- Molecular Formula
- C51H84N16O21
- Molecular Weight
- 1257.3 g/mol
- Sequence
- —
- Type
- Research peptide
- PubChem
- CID 91810664 ↗
Biological targets
Interactions
- Primary target
- Innate repair receptor (IRR): proposed EPOR–β-common receptor (CD131) heterocomplex
- Pathway
- JAK2–STAT3 and PI3K–Akt; NF-κB-linked cytokine modulation
- Mechanism
- Non-erythropoietic 11-residue helix-B surface peptide of erythropoietin; does not engage the erythropoietic EPOR homodimer
- Research area
- Small-fiber neuropathy, innate-immune and tissue-protection research
Physical properties
Handling & Storage
- Appearance
- White to off-white lyophilized powder
- Solubility
- Soluble in sterile or bacteriostatic water; reconstitute prior to use
- Storage
- 2-8 deg C, protect from light
- Country of origin
- USA
Sources & References
Peer-reviewed research
Indexed in NIH PubMed. Provided for research context; not a claim of clinical outcome.
TRANSPLANTATION
Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
2020 · PMID 32345869
Yao M et al.
View Source ↗MOLECULAR MEDICINE (CAMBRIDGE, MASS.)
ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes
2015 · PMID 25387363
Brines M et al.
View Source ↗SCIENTIFIC REPORTS
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
2017 · PMID 29026145
Nairz M et al.
View Source ↗FRONTIERS IN IMMUNOLOGY
Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice
2022 · PMID 36211426
Dennhardt S et al.
View Source ↗EXPERIMENTAL EYE RESEARCH
The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic
2019 · PMID 30876881
O'Leary OE et al.
View Source ↗
⚠ Important research notice
PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly prohibited by law. Products should only be handled by licensed, qualified professionals. Products sold are not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food, or cosmetic.
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